levetiracetam信息详情
左乙拉西坦
Objective A practicable method for separation and quantitative analysis of REV in Levetiracetam tablets by HPLC.───目的采用高效液相色谱法手性拆分左乙拉西坦片中的右旋异构体。
no significant differences between the levetiracetam and valproate groups.───拉西坦组与丙戊酸钠组差异无统计学意义。
Objective: To study the synthesis of levetiracetam.───目的:研究左乙拉西坦的合成方法。
We report the case of a woman with generalized dystonia whose symptoms improved with the use of levetiracetam.───我们报告的情况下,女性全身性肌张力障碍的症状改善使用拉西坦。
The invention relates to a levetiracetam slow release pellet capsule preparation and a preparation method thereof.───本发明涉及一种左乙拉西坦缓释微丸胶囊制剂及其制备方法。
OBJECTIVE: Levetiracetam has been widely used for childhood epilepsy, but there is no high quality evidence to support its use.───目的:左乙拉西坦已经广泛应用于儿童癫癎的治疗中,但尚无高质量证据证明其安全性和有效性。
This study performed a systematic review to evaluate the effectiveness and safety of levetiracetam therapy for childhood epilepsy.───本研究系统评价左乙拉西坦治疗儿童癫癎的有效性和安全性。
CONCLUSIONS: The current evidence shows that levetiracetam therapy is effective for childhood epilepsy.───结论:目前证据表明,左乙拉西坦治疗儿童癫癎有效,但仍需更多实验数据支持。
Since 2004, prescriptions of carbamazepine, phenytoin and valproate decreased while levetiracetam increased.───从2004年,卡马西平、苯妥英和丙戊酸盐的剂量减少了然而左乙拉西坦的剂量增加了。
Objective To explore the effect of levetiracetam (LEV), a new type antiepileptic drug, as an addon therapy on acute postoperative seizures (APOS) in adults with refractory temporal epilepsy.
Screening for 2 - bromo-butyric acid as the starting material, after ammonolysis, esterification, ester amine solution, split, five-step cyclization reaction Levetiracetam.
Here we review the efficacy and safety of levetiracetam monotherapy in treating several types of epilepsy, including newly diagnosed epilepsy, partial epilepsy, generalized epilepsy, etc.
Levetiracetam (Lev) is a novel orally active antiepileptic drug, structurally unrelated to other antiepileptics and with an entirely unique preclinical profile.
Levetiracetam was prepared from L-methionine via reduction-dethiomethylation, esterification, ammonolysis, amidation and intramolecular cyclocondensation reaction with 44.6% overall yield.
Since the patent of levetiracetam has been expired and the development of new antiepileptic drugs has been not satisfied the global antiepileptic drug market would grow slower in the coming years.
Methods: The preparation of levetiracetam is adopting Late Ring-closure route, which can optimize the condition of the compound ammonolysis process.
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